Macrophage NADPH oxidase diseases
NADPH oxidase in macrophages plays a crucial role in generating reactive oxygen species (ROS) to kill pathogens. However, dysregulation of NADPH oxidase can lead to various diseases. Here are some key diseases associated with macrophage NADPH oxidase:
Chronic Granulomatous Disease (CGD)
Description: CGD is a genetic disorder where phagocytes, including macrophages, cannot produce ROS due to defective NADPH oxidase. This leads to recurrent infections and granuloma formation.